As a holistic veterinarian, I’ve seen many female dogs benefit from Symplex F by Standard Process. This supplement is formulated to support the endocrine system, which manages hormone balance, energy, metabolism, and stress response. When hormones are in balance, your dog’s whole body feels the difference—better energy, calmer mood, and improved coat and skin.
Let’s explore what makes Symplex F so effective and how it can naturally support your dog’s health.

What Is Symplex F?
Symplex F is a whole-food-based supplement created by Standard Process, a trusted company that’s been making nutritional products since 1929. The “F” stands for female, and this formula is designed specifically for the unique hormonal and metabolic needs of female dogs.
The supplement supports four key glands that regulate hormones:
- Ovaries: reproductive function and hormone production
- Adrenal glands: stress response and energy regulation
- Thyroid: metabolism and body temperature
- Pituitary gland: the “master gland” that controls hormone signals to all others
By gently nourishing these glands, Symplex F helps restore balance from within—something synthetic medications can’t always achieve.
Key Benefits of Symplex F for Dogs
Here are the main ways this supplement can support your dog’s health:
1. Promotes Hormonal Balance
Helps maintain a healthy hormone rhythm for improved energy, coat quality, and mood stability. This is especially useful for dogs showing signs of hormonal changes such as shedding, mood swings, or sluggishness.
2. Supports Metabolic Health
Encourages healthy nutrient absorption and energy production. Many pet parents notice better appetite control and improved stamina.
3. Strengthens the Immune System
The endocrine system and immune system are closely connected. When one is balanced, the other functions better—helping your dog resist illness and recover more quickly.
4. Improves Skin and Coat
Balanced hormones often mean healthier skin. Many dogs show less itching, flaking, and coat dullness after consistent use.
5. Aids Female Reproductive Health
Supports normal ovarian and uterine function and helps older spayed females maintain steady hormone signals.
6. Natural, Whole-Food Formula
Made without synthetic additives, dyes, or fillers. Every ingredient works with your dog’s body rather than against it.

Ingredient Breakdown
Symplex F combines key minerals and PMG™ (Protomorphogen) extracts—unique to Standard Process. PMGs are specialized cell extracts that help support the healthy structure and function of specific organs.
Each tablet contains:
- Calcium (20 mg): supports bones, heart rhythm, and muscle function
- Sodium (15 mg): maintains hydration and electrolyte balance
- Magnesium citrate: supports metabolism and nutrient absorption
- Bovine ovary PMG™ extract: nourishes ovarian tissues
- Bovine adrenal PMG™ extract: supports stress response and adrenal balance
- Bovine pituitary PMG™ extract: promotes balanced communication between glands
- Bovine thyroid PMG™ extract (processed to reduce thyroxine content): gently supports thyroid function
Additional supportive ingredients include calcium lactate, cellulose, and calcium stearate, which help with nutrient stability and absorption.
These components work together to restore normal glandular activity and overall endocrine harmony.
When I Recommend Symplex F
I often recommend Symplex F for female dogs showing one or more of the following:
- Fatigue, low energy, or poor stress tolerance
- Weight changes unrelated to diet
- Skin or coat issues that fluctuate with hormonal cycles
- Mood swings, restlessness, or anxiety
- Hair thinning along the sides or tail area
- Changes in appetite or digestive upsets
It’s also a valuable supplement for older spayed females who may experience subtle hormonal decline affecting metabolism and mood.
How It Works
Symplex F blends four key PMG complexes that support the main glands of the endocrine system:
- Thyrotrophin PMG™: supports thyroid hormone balance
- Drenatrophin PMG™: nourishes adrenal glands for stress recovery
- Pituitrophin PMG™: helps coordinate communication between glands
- Gonadotrophin PMG™: supports ovarian health and reproductive hormone balance
When these glands work together smoothly, your dog’s metabolism, mood, coat, and immune system stay stronger and more resilient.

Dosage and Administration
General guideline for daily use:
| Dog Size | Suggested Dosage |
|---|---|
| Small (1–20 lbs) | 1 tablet twice daily |
| Medium (21–50 lbs) | 2 tablets twice daily |
| Large (51+ lbs) | 3 tablets twice daily |
How to give it:
- Offer tablets directly or crush and mix with food.
- Giving with meals often improves tolerance.
- Always start slowly and monitor your dog’s response.
Your holistic veterinarian may adjust the dosage based on your dog’s health status and response.
Possible Side Effects and Precautions
Symplex F is generally very well tolerated. Mild digestive upset (soft stool, mild nausea) can occur as the body adjusts to new nutrients.
Call your vet if your dog shows any of the following:
- Persistent vomiting or diarrhea
- Loss of appetite lasting more than a day
- Unusual itching, swelling, or hives (possible sensitivity)
Avoid giving to pregnant or nursing dogs unless your veterinarian recommends it. Always discuss new supplements if your pet is on medication or has an existing health condition.
Integrating Symplex F with Holistic Care
Symplex F fits beautifully into a holistic plan for hormonal and metabolic balance. I often combine it with:
- Cold laser therapy to reduce inflammation and support adrenal recovery
- Whole-food diets that promote steady energy and stable blood sugar
- Probiotics to improve gut and immune health (since gut balance supports hormone balance)
If your dog struggles with fatigue, mood swings, or coat changes, this kind of combined approach often delivers faster, more complete results.
You can schedule an online holistic consultation with me at Journeys Holistic Life for a custom endocrine or hormonal support plan tailored to your dog’s needs.

Final Thoughts
Symplex F by Standard Process is one of my go-to tools for restoring balance in female dogs. It supports the glands that keep hormones steady, energy stable, and mood balanced—without synthetic additives or harsh medications.
If you’d like to try Symplex F for your dog, you can purchase it directly through my store at Journeys Holistic Life, where every product is veterinarian-approved and stored under proper conditions.
Taking small, natural steps toward hormone balance can make a big difference in your dog’s comfort, energy, and long-term health.
Frequently Asked Questions
Symplex® F is a whole-food supplement formulated to support healthy hormone balance in female dogs. It nourishes the ovaries, thyroid, pituitary, and adrenal glands—the key players in the endocrine system. This product is part of the trusted Standard Process line, known for using natural, nutrient-rich ingredients instead of synthetic isolates.
Symplex® F helps restore balance to your dog’s hormonal system by gently supporting the glands that regulate metabolism, mood, and stress. Its unique blend of bovine-derived PMG™ extracts and minerals provides targeted nutrition for:
– Ovaries: supports reproductive hormone balance
– Thyroid: encourages healthy metabolism
– Pituitary: regulates communication between glands
– Adrenal glands: supports stress resilience and steady energy
Together, these nutrients help female dogs maintain consistent energy, a shiny coat, and overall wellbeing.
Symplex® F is easy to give daily. Simply follow the dosage recommended by your veterinarian or based on your dog’s weight. Most pet parents:
– Offer tablets directly as a treat, or
– Crush and mix them into food for convenience
Consistency is key—daily use supports steady hormone balance and long-term results.
Symplex® F is made from natural, whole-food ingredients and is generally very well tolerated. On rare occasions, a mild digestive change (soft stool or reduced appetite) may occur as your dog adjusts. If you notice anything unusual, pause the supplement and check with your holistic or primary care veterinarian.
You can purchase Symplex® F directly from me at Journeys Holistic Life. Buying through a veterinarian ensures you receive authentic Standard Process products stored under proper conditions and matched to your dog’s unique needs.




