Spleen PMG for Dogs: Holistic Vet Guide to Immune Care & Support

The following information is a summary and review based on Dr. Candy’s professional experience and recommendations. Any summary or statement has not been provided nor influenced by the manufacturer.

As a holistic veterinarian, I often meet pet parents looking for ways to strengthen their dog’s immune system or improve digestion. One supplement that I’ve used for many years in my holistic practice is Spleen PMG by Standard Process.

This isn’t a trend or a quick fix. It’s a time-tested supplement that can help balance the spleen and immune system — both of which play major roles in your dog’s long-term health.

Spleen PMG for Dogs by Standard Process

What Is Spleen PMG?

Spleen PMG is a glandular supplement made from porcine (pig) spleen. The name “PMG” stands for Protomorphogen Extract, a special type of extract developed by Dr. Royal Lee, the founder of Standard Process.

Protomorphogens are naturally derived proteins believed to support the healthy function of specific tissues and organs. In this case, Spleen PMG provides targeted support for the spleen, an organ responsible for filtering blood, recycling red blood cells, and regulating immune response.

I often describe the spleen as your dog’s “immune headquarters.” When it’s not functioning properly, your pet may experience fatigue, poor recovery, or a sluggish immune system.

Why the Spleen Matters for Your Dog

The spleen doesn’t always get much attention in traditional veterinary care, but it quietly performs essential work every single day:

  • Cleans and filters blood to remove damaged red cells and pathogens
  • Stores white blood cells and platelets for immune defense
  • Supports digestion and fluid balance through its role in blood quality
  • Contributes to red blood cell production, especially during stress or illness

Because the spleen is tied to both immunity and digestion, supporting it can help your dog’s body stay resilient and balanced.

7550-Spleen-PMG-Tablet-for dogs

How Spleen PMG Supports Dog Health

I’ve seen Spleen PMG help dogs with a wide variety of issues — from chronic infections to low energy. Here’s how it works:

1. Strengthens Immune Function

The spleen plays a key role in fighting infections. Spleen PMG helps support the immune tissues so they can respond effectively to everyday challenges.

2. Promotes Healthy Red Blood Cells

If your dog struggles with anemia or low stamina, Spleen PMG can help by supporting red blood cell production and recycling, improving oxygen delivery throughout the body.

3. Supports Digestion and Detoxification

Healthy spleen function also influences how your dog digests food and eliminates waste. By improving blood filtration, Spleen PMG helps remove toxins more efficiently.

4. Provides Gentle Nutritional Support

Unlike synthetic supplements, Spleen PMG delivers nutrients in their natural, bioavailable form. It contains proteins, enzymes, and trace minerals that nourish cells and tissues.

Key Ingredients and Their Benefits

Each ingredient in Spleen PMG serves a purpose:

  • Bovine Spleen PMG Extract: Supports spleen tissue health, immune function, and blood balance.
  • Calcium Lactate: A highly absorbable form of calcium that supports nerve, muscle, and bone health.
  • Magnesium Citrate: Helps with energy production, heart rhythm, and muscle relaxation.

These nutrients work together to promote healthy cell function throughout the body. I appreciate that Standard Process uses whole-food ingredients that are gentle on the digestive system.

A large brown dog watching as its owner adds a tablet of Spleen PMG to its bowl of food

When I Recommend Spleen PMG for Dogs

Spleen PMG can be a helpful addition to your dog’s care plan if they’re experiencing:

  • Weakened immune response or frequent infections
  • Low red blood cell count or signs of anemia
  • Enlarged or sluggish spleen (as diagnosed by a vet)
  • Slow recovery from illness or surgery
  • Chronic digestive upset or inflammation

Even for generally healthy dogs, I sometimes use Spleen PMG as a preventive supplement during stress, travel, or seasonal immune challenges.

For dogs with chronic inflammation or cancer recovery, I often combine Spleen PMG with cold laser therapy to support circulation and healing.

Dosage and How to Give Spleen PMG

The correct amount depends on your dog’s weight and health needs. As a general guideline:

Dog SizeSuggested AmountTiming
Small dogs (1–20 lbs)1 tablet twice dailyOn an empty stomach
Medium dogs (21–50 lbs)2 tablets twice dailyOn an empty stomach
Large dogs (51+ lbs)3 tablets twice dailyOn an empty stomach

Tips for giving Spleen PMG:

  • Offer on an empty stomach for best absorption.
  • If your dog resists tablets, hide them in a small treat.
  • Stay consistent: same time each day works best.

Always check with your holistic or primary veterinarian before starting a new supplement, especially if your dog takes medication.

Possible Side Effects

Spleen PMG is generally very safe. In rare cases, a dog might experience mild digestive upset (soft stool, gas, or temporary nausea) when first starting.

To minimize this, begin with a smaller dose and gradually increase to the full amount. If symptoms persist or your dog shows signs of an allergic reaction (itching, swelling, difficulty breathing), stop the supplement and contact your veterinarian right away.

Safety Tips and Best Practices

  • Use only as directed for your dog’s size and condition.
  • Monitor energy levels, appetite, and stool quality during the first few weeks.
  • Store in a cool, dry place away from sunlight.
  • Combine with a balanced, whole-food diet and regular exercise for the best results.

Remember, supplements should support, not replace, proper veterinary care.

a Rhodesian Ridgeback gently taking a tablet of Spleen PMG from its owner’s hand like a treat

Where to Buy

To ensure quality and authenticity, always purchase Standard Process supplements directly from a trusted veterinary source. You can order Spleen PMG and other holistic health products directly through me at Journeys Holistic Life.

If you’re unsure whether Spleen PMG is right for your dog, schedule an online holistic consultation with me. We’ll review your pet’s health history, current diet, and any symptoms to create a personalized plan that fits your dog’s unique needs.

Final Thoughts

Supporting your dog’s spleen may not sound exciting, but it’s one of the smartest things you can do for their immune and digestive health.

Spleen PMG offers gentle, effective support that helps your dog feel stronger, more energetic, and better protected against everyday stressors. With the right nutritional foundation and consistent care, your dog can thrive naturally.


Frequently Asked Questions

What is Spleen PMG® by Standard Process?

Spleen PMG® by Standard Process is a glandular supplement made from porcine spleen tissue. It’s formulated to support the spleen’s natural functions, including blood filtration and immune balance. By nourishing spleen cells at a foundational level, this supplement helps your dog’s body remove metabolic waste and maintain healthy immune activity.
You can find authentic Spleen PMG® directly through me at Journeys Holistic Life, where I only offer veterinarian-approved holistic supplements.

How does Spleen PMG® support my dog’s immune system?

The spleen acts as one of your dog’s primary immune organs, producing and storing white blood cells that help fight infections. Spleen PMG® supports these functions by providing tissue-specific nutrients that help the spleen stay strong and responsive. This can lead to better immune regulation, faster recovery, and improved energy.

How often should I give my dog Spleen PMG®?

Dosage depends on your dog’s size, diet, and overall health. As a general guideline, small dogs often take 1 tablet twice daily, medium dogs 2 tablets twice daily, and large dogs 3 tablets twice daily. For best results, give Spleen PMG® on an empty stomach.
I recommend consulting your holistic veterinarian before starting any new supplement to ensure the dosage fits your dog’s specific needs.

Are there any side effects with Spleen PMG®?

Spleen PMG® is very gentle and typically well-tolerated. In rare cases, dogs may experience mild digestive upset (soft stool or temporary nausea) when first starting the supplement. These effects usually resolve as your dog adjusts.
If you notice any unusual reactions, stop the supplement and contact your veterinarian right away.

Can I give Spleen PMG® to other pets?

Yes, Spleen PMG® has been safely used by veterinarians for both dogs and cats for many years. However, dosage and response can vary between species. Always check with your veterinarian before giving Spleen PMG® to pets other than dogs to make sure it’s the right fit for their health plan.